The 'Hourglass' Model of Gut Microbiome-Host Interaction in Health and Disease
The gut hosts trillions of microbes, including over 3,000 species, which interact with dietary components and host tissues, generating diverse bioactive metabolites. These microbial signals are detected by four key pattern recognition receptor (PRR) families:
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Toll-Like Receptors (TLRs): Detect conserved microbial molecules (e.g., lipopolysaccharides).
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NOD-Like Receptors (NLRs): Sense intracellular pathogens and mediate inflammation.
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RIG-I-Like Receptors (RLRs): Recognise viral RNA and trigger antiviral defences.
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C-Type Lectin Receptors (CLRs): Bind microbial polysaccharides, aiding bacterial and fungal recognition.
PRRs are central to host-microbiome interactions, making them promising therapeutic targets for addressing the impact of gut dysbiosis and related conditions.
How veMico’s Postbiotics Work
​"Empowering the Host to Thrive Naturally"​
Unlike microbiota modulation, veMico’s postbiotics directly engage the host's immune pathways for targeted, predictable benefits.
Why veMico’s Approach Matters
​​"A Reliable, Science-Backed Alternative"
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Traditional probiotics and prebiotics face key limitations: ​​
Inconsistent Efficacy:
Microbiome variability leads to unpredictable outcomes.
Poor Colonisation:
Probiotics struggle to establish or persist in the gut.
Side Effects:
Some cause bloating or Small Intestinal Bacterial Overgrowth (SIBO).
Unreliable Microbiota Modulation:
Difficult to control and varies between individuals, increasing the risk of unintended effects.
How veMico Overcomes These Challenges:​
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By targeting the host’s response mechanisms directly through postbiotics, our solutions strengthen natural defences by interacting with conserved immune pathways, providing a reliable, science-backed way to improve gut health and systemic well-being.
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Why Postbiotics Are Better
Unlike microbiota-focused approaches, veMico’s postbiotics:
Ensure Predictable Outcomes:
Directly engage the host’s immune system and gut barrier.
Deliver Targeted, Sustainable Results:
Act through conserved immune mechanisms.
Bypass Microbiota Complexity:
Avoid the need to engineer or manipulate microbial communities.